Description: Phosphorylation of T2511 in the degron of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.
Participants: (1) Neurogenic locus notch homolog protein 1 (NOTCH1) (2) F-box/WD repeat-containing protein 7 (FBXW7)
(1) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.Oberg et al. J. Biol. Chem. (2001) (2) SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.Wu et al. Mol. Cell. Biol. (2001)
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