Switch #:
SWTI000016
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).

Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Glycogen synthase kinase-3 beta (GSK3B)

Interactions
Interaction #1 TP53 - GSK3B

Interfaces
(1) MOD_GSK3_1 motif (30NVLSPLPS37) in Cellular tumor antigen p53 (TP53)
(2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S37 on Cellular tumor antigen p53 (TP53)) of the Cellular tumor antigen p53 (TP53) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S37: DNA-dependent protein kinase catalytic subunit (PRKDC)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S37 : Serine/threonine-protein kinase ATR (ATR), Serine/threonine-protein kinase Chk1 (CHEK1), Serine/threonine-protein kinase Chk2 (CHEK2), MAP kinase-activated protein kinase 5 (MAPKAPK5), DNA-dependent protein kinase catalytic subunit (PRKDC).

Context
Switch localisation
ELM curated: cytosol, nucleus
Inferred: cytosol, nucleus


Switch pathways
Inferred: Wnt signaling pathway, PI3K-Akt signaling pathway, Neurotrophin signaling pathway, Cell cycle
References

(1) Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.
Turenne et al. BMC Cell Biol. (2001)




Loading visualisation

↑