Description: Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
Participants: (1) Protein sprouty homolog 2 (SPRY2) (2) E3 ubiquitin-protein ligase CBL (CBL)
(1) Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.Sun et al. PLoS ONE (2010)
Your browser does not support iframes.