Description: Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
Participants: (1) Epidermal growth factor receptor (EGFR) (2) E3 ubiquitin-protein ligase CBL (CBL)
(1) Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.Sun et al. PLoS ONE (2010)
