Switch #:
Switch type:
Switch subtype:
Composite binding site formation

Binding of to Coi1, an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone jasmonate to COI1, as this pre-assembled complex provides a composite binding site for the degron motif in the JAZ protein. Subsequent ubiquitylation of the JAZ protein by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to jasmonate.

(2) Coi1

This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step
1Interaction #1 - Coi1

(1) N-[(3R,7S)-(+)-7-iso-Jasmonoyl]-(S)-isoleucine in
(2) Coi1
2Interaction #2 - Interaction #1 - - Coi1

Requires Interaction #1 - - Coi1

(3) DEG_SCF_COI1_1 motif (251QARKASLARFLEKRKERV268) in
(4) Interaction #1 - - Coi1

(1) COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine.
Katsir et al. Proc. Natl. Acad. Sci. U.S.A. (2008)

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