Switch #:
SWTI000501
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).

Participants:
(1) Paxillin (PXN)
(2) Focal adhesion kinase 1 (PTK2)

Interactions
Interaction #1 PXN - PTK2

Interfaces
(1) LIG_FAT_LD_1 motif (4LDALLADLE12) in Paxillin (PXN)
(2) Focal adhesion targeting region (914-1052) in Focal adhesion kinase 1 (PTK2)

Interaction Regulation
Alternative splicing Abrogation of the Paxillin (PXN) LIG_FAT_LD_1 motif - Focal adhesion kinase 1 (PTK2) Focal adhesion targeting region interaction

Context
Switch localisation
ELM curated: cytosol, focal adhesion, plasma membrane, intracellular
Inferred: lamellipodium, cell cortex, focal adhesion


Switch pathways
Inferred: VEGF signaling pathway, Chemokine signaling pathway, Regulation of actin cytoskeleton, Leukocyte transendothelial migration, Focal adhesion
References

(1) Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta.
Tumbarello et al. J. Cell. Sci. (2005)




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