Switch #:
SWTI000478
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the Clathrin II-binding motif of Myc box-dependent-interacting protein 1 (BIN1), abrogating binding to Clathrin heavy chain 1 (CLTC).

Participants:
(1) Myc box-dependent-interacting protein 1 (BIN1)
(2) Clathrin heavy chain 1 (CLTC)

Interactions
Interaction #1 BIN1 - CLTC

Interfaces
(1) LIG_Clathr_ClatBox_2 motif (415IPWDLW420) in Myc box-dependent-interacting protein 1 (BIN1)
(2) Clathrin propeller repeat (19-234) in Clathrin heavy chain 1 (CLTC)

Interaction Regulation
Alternative splicing Abrogation of the Myc box-dependent-interacting protein 1 (BIN1) LIG_Clathr_ClatBox_2 motif - Clathrin heavy chain 1 (CLTC) Clathrin propeller repeat interaction

Context
Switch localisation
ELM curated: cytoskeleton, cytosol, clathrin-coated endocytic vesicle
References

(1) Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.
Ramjaun et al. J. Neurochem. (1998)




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