Description: Alternative splicing removes the mitochondrial localisation signal (MLS) motif of Carnitine O-acetyltransferase (CRAT), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A). As a result, Isoform SM-1200 of Carnitine O-acetyltransferase (CRAT), which lacks the MLS, is located in peroxisomes due to a PTS1 motif in its C-terminus.
Participants: (1) Carnitine O-acetyltransferase (CRAT) (2) Mitochondrial import receptor subunit TOM70 (TOMM70A)
(1) Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism. et al. J. Lipid Res. (2010) (2) Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.Corti et al. Biochem. J. (1994)
