Switch #:
SWTI000410
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.

Participants:
(1) E3 ubiquitin-protein ligase CBL (CBL)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 CBL - CRK

Interfaces
(1) ELM:LIG_SH2_IB motif (770EDDGYDVPKPP780) in E3 ubiquitin-protein ligase CBL (CBL)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y774 on E3 ubiquitin-protein ligase CBL (CBL)) of the E3 ubiquitin-protein ligase CBL (CBL) LIG_SH2_IB motif - Adapter molecule crk (CRK) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y774 : Tyrosine-protein kinase Yes (YES1), Tyrosine-protein kinase ABL1 (Abl1), Insulin receptor (Insr), Tyrosine-protein kinase Lck (LCK), Proto-oncogene tyrosine-protein kinase Src (SRC), Tyrosine-protein kinase Fyn (FYN), Tyrosine-protein kinase SYK (SYK).

Context
Switch localisation
Inferred: cytosol, nucleus, plasma membrane


Switch pathways
Inferred: Insulin signaling pathway, ErbB signaling pathway
References

(1) SH2 domains recognize contextual peptide sequence information to determine selectivity.
Liu et al. Mol. Cell Proteomics (2010)




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