Switch #:
SWTI000397
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y174 in the SH2-binding motif of Proto-oncogene vav (VAV1) induces binding to the SH2 domain-containing adapter protein B (SHB) protein.

Participants:
(1) Proto-oncogene vav (VAV1)
(2) SH2 domain-containing adapter protein B (SHB)

Interactions
Interaction #1 VAV1 - SHB

Interfaces
(1) ELM:LIG_SH2_IIB motif (165NEEAEGDEIYEDLMRS180) in Proto-oncogene vav (VAV1)
(2) SH2 domain (410-485) in SH2 domain-containing adapter protein B (SHB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y174 on Proto-oncogene vav (VAV1)) of the Proto-oncogene vav (VAV1) LIG_SH2_IIB motif - SH2 domain-containing adapter protein B (SHB) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y174 : Tyrosine-protein kinase Lck (LCK).

Context
Switch localisation
Inferred: plasma membrane
References

(1) Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.
Lindholm et al. Eur. J. Biochem. (2002)




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