Switches.ELM

Switch #:

SWTI000203

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S95 and S109 and S111 adjacent to the EB1-binding motif of Kinesin-like protein KIF2C (KIF2C) by Aurora kinase B (AURKB) and Aurora kinase B (AURKB) and Aurora kinase B (AURKB) inhibits its interaction with Microtubule-associated protein RP/EB family member 1 (MAPRE1), thereby inhibiting microtubule tip tracking.

Participants:
(1) Kinesin-like protein KIF2C (KIF2C)
(2) Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Interactions

Interaction #1 KIF2C - MAPRE1

Interfaces
(1) LIG_SxIP_EBH_1 motif (₉₃RRSVNSKIPAPK₁₀₄) in Kinesin-like protein KIF2C (KIF2C)
(2) EB1-like C-terminal motif_(209-248) in Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S₉₅, S₁₀₉ and S₁₁₁ on Kinesin-like protein KIF2C (KIF2C)) of the Kinesin-like protein KIF2C (KIF2C) LIG_SxIP_EBH_1 motif - Microtubule-associated protein RP/EB family member 1 (MAPRE1) EB1-like C-terminal motif interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₉₅: Aurora kinase B (AURKB); S₁₀₉: Aurora kinase B (AURKB); S₁₁₁: Aurora kinase B (AURKB)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₉₅ : Aurora kinase B (AURKB). S₁₀₉ : Aurora kinase B (AURKB). S₁₁₁ : Aurora kinase B (AURKB).

Context

Switch cell cycle phase
Curated: mitotic prometaphase

References

(1) An EB1-binding motif acts as a microtubule tip localization signal.
Honnappa et al. Cell (2009)

(2) MCAK associates with the tips of polymerizing microtubules.
Moore et al. J. Cell Biol. (2005)