Switch #:
SWTI000177
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.

Participants:
(1) Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)
(2) Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Interactions
Interaction #1 FCGR2B - INPP5D

Interfaces
(1) LIG_TYR_ITIM motif (290ITYSLL295) in Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)
(2) SH2 domain (5-86) in Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y292 on Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)) of the Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) LIG_TYR_ITIM motif - Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y292 : Tyrosine-protein kinase Fyn (FYN), Tyrosine-protein kinase Blk (BLK), Tyrosine-protein kinase Lyn (LYN).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol
Inferred: plasma membrane


Switch pathways
Inferred: B cell receptor signaling pathway, Fc gamma R-mediated phagocytosis
References

(1) Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms.
Van den Herik-Oudijk et al. Blood (1995)

(2) Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation.
Fong et al. Immunol. Lett. (1996)




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