Description: Phosphorylation of S422 by Serine/threonine-protein kinase mTOR (MTOR) (as part of mTORC2 complex) in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk1 (SGK1) induces intramolecular binding and kinase cis-activation.
Participants: (1) Serine/threonine-protein kinase Sgk1 (SGK1)
(1) The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.Biondi et al. EMBO J. (2001) (2) mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).García-Martínez et al. Biochem. J. (2008)
