Switch #:
SWTI000146
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1063 in the PTB-binding motif of Proto-oncogene tyrosine-protein kinase receptor Ret (Ret) induces binding to the Docking protein 1 (Dok1) protein.

Participants:
(1) Proto-oncogene tyrosine-protein kinase receptor Ret (Ret)
(2) Docking protein 1 (Dok1)

Interactions
Interaction #1 Ret - Dok1

Interfaces
(1) LIG_PTB_Phospho_1 motif (1057WIENKLY1063) in Proto-oncogene tyrosine-protein kinase receptor Ret (Ret)
(2) PTB domain (IRS-1 type) (151-254) in Docking protein 1 (Dok1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1063 on Proto-oncogene tyrosine-protein kinase receptor Ret (Ret)) of the Proto-oncogene tyrosine-protein kinase receptor Ret (Ret) LIG_PTB_Phospho_1 motif - Docking protein 1 (Dok1) PTB domain (IRS-1 type) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1063 : Proto-oncogene tyrosine-protein kinase receptor Ret (Ret).

Additional Information
Structural information: 1UEF
Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
References

(1) Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domain.
Shi et al. J. Biol. Chem. (2004)




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