Switch #:
SWTI000143
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y250 in the PTB-binding motif of Middle T antigen induces binding to the SHC-transforming protein 1 (Shc1) protein.

Participants:
(1) Middle T antigen
(2) SHC-transforming protein 1 (Shc1)

Interactions
Interaction #1 - Shc1

Interfaces
(1) LIG_PTB_Phospho_1 motif (244LLSNPTY250) in Middle T antigen
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (Shc1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y250 on Middle T antigen) of the Middle T antigen LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (Shc1) Phosphotyrosine interaction domain (PTB/PID) interaction

Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
References

(1) Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine.
Trüb et al. J. Biol. Chem. (1995)




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