Switch #:
SWTI000084
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S200 in the Pin1-binding motif of Gephyrin (Gphn) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Gephyrin (Gphn)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Gphn - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (197PTTSPH202) in Gephyrin (Gphn)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S200 on Gephyrin (Gphn)) of the Gephyrin (Gphn) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: cytoplasm
References

(1) Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function.
Zita et al. EMBO J. (2007)




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