Description: Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.
Participants: (1) Linker for activation of T-cells family member 1 (LAT) (2) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
(1) The LAT story: a tale of cooperativity, coordination, and choreography.Balagopalan et al. Cold Spring Harb Perspect Biol (2010) (2) Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences.Houtman et al. Biochemistry (2004)
