Switches.ELM

Switch #:

SWTI000711

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S122 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.

Participants:
(1) Metallothionein expression activator (ACE2)
(2) Exportin-1 (CRM1)

Interactions

Interaction #1 ACE2 - CRM1

Interfaces
(1) ELM:TRG_NES motif (₁₂₂SGTAIFGFLGHNKTLSISSLQQSILNMSK₁₅₀) in Metallothionein expression activator (ACE2)
(2) Exportin 1-like protein_(111-256) in Exportin-1 (CRM1)

Interaction Regulation
PTM-dependent Inhibition (Phosphorylation of S₁₂₂ on Metallothionein expression activator (ACE2)) of the Metallothionein expression activator (ACE2) TRG_NES motif - Exportin-1 (CRM1) Exportin 1-like protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₁₂₂: Serine/threonine-protein kinase CBK1 (CBK1)

References

(1) The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry.
Mazanka et al. PLoS Biol. (2008)