Switch #:
SWTI000701
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1262 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to Growth factor receptor-bound protein 2 (GRB2).

Participants:
(1) Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) Growth factor receptor-bound protein 2 (GRB2)

Interactions
Interaction #1 ERBB3 - GRB2

Interfaces
(1) LIG_SH2_GRB2 motif (1262YMNR1265) in Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1262 on Receptor tyrosine-protein kinase erbB-3 (ERBB3)) of the Receptor tyrosine-protein kinase erbB-3 (ERBB3) LIG_SH2_GRB2 motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol
References

(1) Phosphotyrosine interactome of the ErbB-receptor kinase family.
Schulze et al. Mol. Syst. Biol. (2005)




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