Switch #:
SWTI000699
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1125 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Adapter molecule crk (CRK).

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 EGFR - CRK

Interfaces
(1) LIG_SH2_SRC motif (1125YQDP1128) in Epidermal growth factor receptor (EGFR)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1125 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_SRC motif - Adapter molecule crk (CRK) SH2 domain interaction


Context
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)




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