Switch #:
SWTI000694
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T145 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by RAC-alpha serine/threonine-protein kinase (AKT1) inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.

Participants:
(1) Cyclin-dependent kinase inhibitor 1 (CDKN1A)
(2) Proliferating cell nuclear antigen (PCNA)

Interactions
Context
References

(1) Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.
Rössig et al. Mol. Cell. Biol. (2001)




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