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The KEN-box motif of APC/C-CDH1 modulator 1 (ACM1) binds to the substrate recruitment site of APC/C activator protein CDH1 (CDH1), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), and thereby blocks recruitment, and subsequent targeting for proteasomal degradation, of the Cdh1 substrate Probable serine/threonine-protein kinase HSL1 (HSL1). Degradation of Probable serine/threonine-protein kinase HSL1 (HSL1) is required for mitotic exit and maintenance of the G1 phase of the cell cycle and is allowed by Cdc20-dependent degradation of APC/C-CDH1 modulator 1 (ACM1) in anaphase.

(1) APC/C-CDH1 modulator 1 (ACM1)
(2) APC/C activator protein CDH1 (CDH1)
(3) Probable serine/threonine-protein kinase HSL1 (HSL1)


(1) Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1.
Burton et al. EMBO J. (2011)

(2) Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex.
Choi et al. J. Biol. Chem. (2008)

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