Description: Phosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).
Participants: (1) Neural cell adhesion molecule L1 (L1CAM) (2) AP-2 complex subunit mu (AP2M1)
(1) L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.Schaefer et al. J. Cell Biol. (2002)
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