Switch #:
SWTI000669
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Sumoylation of K4 in Estrogen receptor beta (ESR2) is inhibited by ubiquitination K4. This destabilises ESR2 increasing its turnover (see also switch details)

Participants:
(1) Estrogen receptor beta (ESR2)
(2) SUMO-conjugating enzyme UBC9 (UBE2I)

Interactions
Interaction #1 ESR2 - UBE2I

Interfaces
(1) ELM:MOD_SUMO_PHOS motif (4KNSP7) in Estrogen receptor beta (ESR2)
(2) Ubiquitin-conjugating enzyme (8-152) in SUMO-conjugating enzyme UBC9 (UBE2I)

Interaction Regulation
PTM-dependent Inhibition (MOD:00492 at K4 on Estrogen receptor beta (ESR2)) of the Estrogen receptor beta (ESR2) MOD_SUMO_PHOS motif - SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme interaction

References

(1) Identification of estrogen receptor β as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen synthase kinase 3β.
Picard et al. Mol. Cell. Biol. (2012)




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