Switch #:
SWTI000654
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Ras GTPase-activating protein 1 (RASA1).

Participants:
(1) Paxillin (PXN)
(2) Ras GTPase-activating protein 1 (RASA1)

Interactions
Interaction #1 PXN - RASA1

Interfaces
(1) ELM:LIG_SH2_IB motif (118YSFP121) in Paxillin (PXN)
(2) Focal adhesion targeting region (351-441) in Ras GTPase-activating protein 1 (RASA1)

Interaction Regulation
Alternative splicing Abrogation of the Paxillin (PXN) LIG_SH2_IB motif - Ras GTPase-activating protein 1 (RASA1) Focal adhesion targeting region interaction

References

(1) Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta.
Tumbarello et al. J. Cell. Sci. (2005)




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