Switch #:
SWTI000646
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1).

Participants:
(1) Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1)
(2) Calmodulin (CALM1)

Interactions
Interaction #1 ATP2B1 - CALM1

Interfaces
(1) ELM:LIG_IQ_2 motif (1114IQTQIRVVNAFRSSL1128) in Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1)
(2) EF-hand domain pair (85-146) in Calmodulin (CALM1)

Interaction Regulation
Alternative splicing Inhibition of the Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1) LIG_IQ_2 motif - Calmodulin (CALM1) EF-hand domain pair interaction

Context

Switch pathways
Inferred: Salivary secretion, Calcium signaling pathway
References

(1) Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.
Strehler et al. Physiol. Rev. (2001)




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