Description: Alternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Trem-like transcript 1 protein (TREML1), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
Participants: (1) Trem-like transcript 1 protein (TREML1) (2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
(1) Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.Barrow et al. J. Immunol. (2004)
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