Description: Alternative splicing removes the PDZ-binding motif of Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1), abrogating binding to Disks large homolog 4 (DLG4). Binding of the PDZ domain of DLG4 suppresses an ER-retention motif in GRIN1, promoting its cell surface expression in a splice variant-specific manner.
Participants: (1) Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) (2) Disks large homolog 4 (DLG4)
(1) PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants.Standley et al. Neuron (2000)
