Description: Alternative splicing removes the PDZ-binding motif of Isoform Kalirin-7 of Kalirin (Kalrn), abrogating binding to Disks large homolog 4 (Dlg4). Isoform Kalirin-7 of Kalirin (Kalrn) is the most prevalent isoform in the adult rat hippocampus where it locates to the postsynaptic density via an interaction with Dlg4 and regulates dendritic morphogenesis.
Participants: (1) Isoform Kalirin-7 of Kalirin (Kalrn) (2) Disks large homolog 4 (Dlg4)
(1) The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis.Penzes et al. Neuron (2001) (2) Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons.Ma et al. J. Neurosci. (2008)
