Switch #:
SWTI000623
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y185 in the SH2-binding motif of Disabled homolog 1 (Dab1) induces binding to Neuronal proto-oncogene tyrosine-protein kinase Src (Src).

Participants:
(1) Disabled homolog 1 (Dab1)
(2) Neuronal proto-oncogene tyrosine-protein kinase Src (Src)

Interactions
Interaction #1 Dab1 - Src

Interfaces
(1) ELM:LIG_SH2_IA motif (185YQTI188) in Disabled homolog 1 (Dab1)
(2) SH2 domain (156-253) in Neuronal proto-oncogene tyrosine-protein kinase Src (Src)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y185 on Disabled homolog 1 (Dab1)) of the Disabled homolog 1 (Dab1) LIG_SH2_IA motif - Neuronal proto-oncogene tyrosine-protein kinase Src (Src) SH2 domain interaction

Context
Switch localisation
ELM curated: cytosol
References

(1) Splice-mediated motif switching regulates Disabled-1 phosphorylation and SH2 domain interactions.
Gao et al. (2012)




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