Description: Phosphorylation of Y232 in the SH2-binding motif of Disabled homolog 1 (Dab1) induces binding to Adapter molecule crk (Crk).
Participants: (1) Disabled homolog 1 (Dab1) (2) Adapter molecule crk (Crk)
(1) Splice-mediated motif switching regulates Disabled-1 phosphorylation and SH2 domain interactions.Gao et al. (2012) (2) Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.Ballif et al. Curr. Biol. (2004) (3) Interaction between Dab1 and CrkII is promoted by Reelin signaling.Chen et al. J. Cell. Sci. (2004) (4) Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.Huang et al. Biochem. Biophys. Res. Commun. (2004)
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