Description: Phosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).
Participants: (1) Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) (2) AP-2 complex subunit mu (AP2M1)
(1) Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage.Thieman et al. J. Biol. Chem. (2009) (2) Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.Nakano-Kobayashi et al. EMBO J. (2007)
