Switches.ELM

Switch #:

SWTI000609

Switch type:
Binary

Description:
Alternative splicing removes the nuclear export signal (NES) of Catenin delta-1 (CTNND1), abrogating binding to Exportin-1 (XPO1). Despite demonstration of the importance of the NES for removing Catenin delta-1 (CTNND1) from the nucleus, those isoforms without NES are rarely found in the nucleus.

Participants:
(1) Catenin delta-1 (CTNND1)
(2) Exportin-1 (XPO1)

Interactions

Interaction #1 CTNND1 - XPO1

Interfaces
(1) TRG_NES_CRM1_1 motif (₉₄₂ESLEEELDVLVLDDE₉₅₆) in Catenin delta-1 (CTNND1)
(2) Exportin 1-like protein_(123-268) in Exportin-1 (XPO1)

Interaction Regulation
Alternative splicing Abrogation of the Catenin delta-1 (CTNND1) TRG_NES_CRM1_1 motif - Exportin-1 (XPO1) Exportin 1-like protein interaction

Context

Switch localisation
Curated: nucleus
ELM curated: nucleus, cytosol

Inferred: cytosol

References

(1) Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression.
van Hengel et al. Proc. Natl. Acad. Sci. U.S.A. (1999)