Switch #:
SWTI000608
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) of E3 ubiquitin-protein ligase Mdm2 (MDM2), abrogating binding to Exportin-1 (XPO1).

Participants:
(1) E3 ubiquitin-protein ligase Mdm2 (MDM2)
(2) Exportin-1 (XPO1)

Interactions
Interaction #1 MDM2 - XPO1

Interfaces
(1) ELM:TRG_NES_CRM1_2 motif (190SLSFDESLALCVI202) in E3 ubiquitin-protein ligase Mdm2 (MDM2)
(2) Exportin 1-like protein (123-268) in Exportin-1 (XPO1)

Interaction Regulation
Alternative splicing Abrogation of the E3 ubiquitin-protein ligase Mdm2 (MDM2) TRG_NES_CRM1_2 motif - Exportin-1 (XPO1) Exportin 1-like protein interaction

Context
References

(1) MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.
Bartel et al. Mol. Cancer Res. (2004)

(2) MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal.
Schuster et al. Mol. Cancer Res. (2007)




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