Description: Alternative splicing removes the nuclear export signal (NES) of E3 ubiquitin-protein ligase Mdm2 (MDM2), abrogating binding to Exportin-1 (XPO1).
Participants: (1) E3 ubiquitin-protein ligase Mdm2 (MDM2) (2) Exportin-1 (XPO1)
(1) MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.Bartel et al. Mol. Cancer Res. (2004) (2) MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal.Schuster et al. Mol. Cancer Res. (2007)
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