Switch #: SWTI000607

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) of E3 ubiquitin-protein ligase Mdm2 (MDM2), abrogating binding to Importin subunit alpha-1 (KPNA1). The exclusion from the nucleus is not complete however, as another NLS (466-473) is speculated to target splice variants to the nucleus, however, to the annotator it seems more likely that splice variants can dimerise with full-length MDM2 and be simultaneously transported into nucleus.

Participants:
(1) E3 ubiquitin-protein ligase Mdm2 (MDM2)
(2) Importin subunit alpha-1 (KPNA1)

(1) MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal.
Schuster et al. Mol. Cancer Res. (2007)