Description: Alternative splicing removes the PDZ-binding motif of Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3) is expressed at the leading edge of membrane ruffles. The interaction of CLCN3 with SLC9A3R1 is important for localising outwardly rectifying chloride channels at the leading edge.
Participants: (1) Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3) (2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
(1) ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC.Ogura et al. FASEB J. (2002)
