Switch #:
SWTI000591
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the SH3-binding motif of Synaptojanin-2 (Synj2), abrogating binding to Endophilin-A2 (Sh3gl1). Endophilin-A1 (Sh3gl2) and Endophilin-A3 (Sh3gl3) were also shown to bind in this study.

Participants:
(1) Synaptojanin-2 (Synj2)
(2) Endophilin-A2 (Sh3gl1)

Interactions
Interaction #1 Synj2 - Sh3gl1

Interfaces
(1) LIG_SH3_2 motif (1120PHPPQR1125) in Synaptojanin-2 (Synj2)
(2) Variant SH3 domain (306-365) in Endophilin-A2 (Sh3gl1)

Interaction Regulation
Alternative splicing Abrogation of the Synaptojanin-2 (Synj2) LIG_SH3_2 motif - Endophilin-A2 (Sh3gl1) Variant SH3 domain interaction

Context
Switch localisation
ELM curated: cytosol, focal adhesion, plasma membrane
Inferred: insoluble fraction
References

(1) Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals.
Nemoto et al. J. Biol. Chem. (2001)




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