Switch #:
SWTI000587
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S89 in the 14-3-3-binding motif of WW domain-containing transcription regulator protein 1 (WWTR1) induces binding to 14-3-3 protein epsilon (YWHAE), retaining phosphorylated WWTR1 in the cytosol, negatively regulating its function.

Participants:
(1) WW domain-containing transcription regulator protein 1 (WWTR1)
(2) 14-3-3 protein epsilon (YWHAE)

Interactions
Interaction #1 WWTR1 - YWHAE

Interfaces
(1) LIG_14-3-3_1 motif (86RSHSSP91) in WW domain-containing transcription regulator protein 1 (WWTR1)
(2) 14-3-3 protein (4-239) in 14-3-3 protein epsilon (YWHAE)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S89 on WW domain-containing transcription regulator protein 1 (WWTR1)) of the WW domain-containing transcription regulator protein 1 (WWTR1) LIG_14-3-3_1 motif - 14-3-3 protein epsilon (YWHAE) 14-3-3 protein interaction

Context
Switch localisation
ELM curated: nucleus, cytosol, internal side of plasma membrane
Inferred: cytosol
References

(1) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
Kanai et al. EMBO J. (2000)




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