Switch #:
SWTI000585
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the EVH1-binding motif of Xin actin-binding repeat-containing protein 1 (XIRP1), abrogating binding to Vasodilator-stimulated phosphoprotein (VASP).

Participants:
(1) Xin actin-binding repeat-containing protein 1 (XIRP1)
(2) Vasodilator-stimulated phosphoprotein (VASP)

Interactions
Interaction #1 XIRP1 - VASP

Interfaces
(1) LIG_EVH1_1 motif (22LPLPP26) in Xin actin-binding repeat-containing protein 1 (XIRP1)
(2) WH1 domain (1-110) in Vasodilator-stimulated phosphoprotein (VASP)

Interaction Regulation
Alternative splicing Abrogation of the Xin actin-binding repeat-containing protein 1 (XIRP1) LIG_EVH1_1 motif - Vasodilator-stimulated phosphoprotein (VASP) WH1 domain interaction

Context
Switch localisation
ELM curated: cytosol, plasma membrane
References

(1) Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.
van der Ven et al. Exp. Cell Res. (2006)




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