Switch #: SWTI000583

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the 14-3-3-binding motif of Isoform Short of Huntingtin-associated protein 1 (Hap1), abrogating binding to 14-3-3 protein zeta/delta (Ywhaz). The association of HAP1A (Isoform Short of Huntingtin-associated protein 1 (Hap1)) with 14-3-3 protein zeta/delta (Ywhaz) inhibits binding of the splice variant to members of the kinesin light chain family and diminishes trafficking of Hap1 to neural processes and neurite tips. The result is a decrease in neurite outgrowth.

Participants:
(1) Isoform Short of Huntingtin-associated protein 1 (Hap1)
(2) 14-3-3 protein zeta/delta (Ywhaz)

(1) 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
Rong et al. J. Biol. Chem. (2007)