Switch #:
SWTI000581
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the VHL-hydroxyproline-modified binding motif of Hypoxia-inducible factor 3-alpha (HIF3A), abrogating binding to Von Hippel-Lindau disease tumor suppressor (VHL). Other studies have shown that the HIF-3 alpha-4 splice variant (Isoform HIF-3alpha4 of Hypoxia-inducible factor 3-alpha (HIF3A)) can act as a dominant negative form with tumour-suppressive activity (see Maynard et al. (2007) (here)).

Participants:
(1) Hypoxia-inducible factor 3-alpha (HIF3A)
(2) Von Hippel-Lindau disease tumor suppressor (VHL)

Interactions
Context
References

(1) Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.
Maynard et al. J. Biol. Chem. (2003)




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