Description: Alternative splicing removes the nuclear export signal (NES) of Protein PML (PML), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.
Participants: (1) Protein PML (PML) (2) Exportin-1 (XPO1)
(1) A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals.Henderson et al. Exp. Cell Res. (2000) (2) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.Fagioli et al. Oncogene (1992) (3) Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein.Jul-Larsen et al. BMC Mol. Biol. (2010)
