Description: Alternative splicing removes the nuclear localisation signal (NLS) of Protein PML (PML), abrogating binding to Importin subunit alpha-1 (KPNA1) and import into the nucleus.
Participants: (1) Protein PML (PML) (2) Importin subunit alpha-1 (KPNA1)
(1) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.Fagioli et al. Oncogene (1992) (2) SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.Duprez et al. J. Cell. Sci. (1999) (3) Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein.Jul-Larsen et al. BMC Mol. Biol. (2010)
