Description: Alternative splicing removes the mitochondrial localisation signal (MLS) motif of Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into the mitochondria.
Participants: (1) Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) (2) Mitochondrial import receptor subunit TOM70 (TOMM70A)
(1) The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species.Ladner et al. J. Biol. Chem. (1997)
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