Switch #:
SWTI000562
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the di-arginine ER-retention motif of Glutamate receptor, ionotropic kainate 1 (Grik1), abrogating binding to Coatomer subunit beta (COPB1).

Participants:
(1) Glutamate receptor, ionotropic kainate 1 (Grik1)
(2) Coatomer subunit beta (COPB1)

Interactions
Interaction #1 Grik1 - COPB1

Interfaces
(1) ELM:TRG_ER_diArg_2 motif (937CHQRR941) in Glutamate receptor, ionotropic kainate 1 (Grik1)
(2) Adaptin N terminal region (18-539) in Coatomer subunit beta (COPB1)

Interaction Regulation
Alternative splicing Abrogation of the Glutamate receptor, ionotropic kainate 1 (Grik1) TRG_ER_diArg_2 motif - Coatomer subunit beta (COPB1) Adaptin N terminal region interaction

References

(1) Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal.
Ren et al. J. Biol. Chem. (2003)




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