Switch #:
SWTI000561
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Glutamate receptor, ionotropic kainate 1 (Grik1), abrogating binding to Glutamate receptor-interacting protein 1 (Grip1). The ER retention of Grik1 splice variants can be inhibited by PKC phosphorylation and association with a PDZ domain-containing protein. Also shown that the PDZ-binding containing proteins PSD95 and syntenin are able to bind.

Participants:
(1) Glutamate receptor, ionotropic kainate 1 (Grik1)
(2) Glutamate receptor-interacting protein 1 (Grip1)

Interactions
Context
References

(1) Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.
Hirbec et al. Neuron (2003)




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