Description: Alternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Sialic acid-binding Ig-like lectin 12 (Siglec12), abrogating binding to Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6).
Participants: (1) Sialic acid-binding Ig-like lectin 12 (Siglec12) (2) Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6)
(1) Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.Ulyanova et al. J. Biol. Chem. (2001)
Your browser does not support iframes.