Switch #:
SWTI000557
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Sialic acid-binding Ig-like lectin 12 (Siglec12), abrogating binding to Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6).

Participants:
(1) Sialic acid-binding Ig-like lectin 12 (Siglec12)
(2) Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6)

Interactions
Context
Switch localisation
ELM curated: cytosol
References

(1) Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.
Ulyanova et al. J. Biol. Chem. (2001)




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