Switch #:
SWTI000543
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) of F-box/WD repeat-containing protein 7 (FBXW7), abrogating binding to Importin subunit alpha-1 (KPNA1). There are two other NLS motifs in the protein, meaning the isoform can still enter the nucleus.

Participants:
(1) F-box/WD repeat-containing protein 7 (FBXW7)
(2) Importin subunit alpha-1 (KPNA1)

Interactions
Interaction #1 FBXW7 - KPNA1

Interfaces
(1) TRG_NLS_MonoCore_2 motif (10SKRRRT15) in F-box/WD repeat-containing protein 7 (FBXW7)
(2) Armadillo/beta-catenin-like repeat (115-451) in Importin subunit alpha-1 (KPNA1)

Interaction Regulation
Alternative splicing Inhibition of the F-box/WD repeat-containing protein 7 (FBXW7) TRG_NLS_MonoCore_2 motif - Importin subunit alpha-1 (KPNA1) Armadillo/beta-catenin-like repeat interaction

Context
Switch localisation
Curated: cytosol
ELM curated: Nuclear pore, nucleus, NLS-dependent protein nuclear import complex
Inferred: nucleoplasm
References

(1) A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.
Welcker et al. Curr. Biol. (2004)




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