Switch #:
SWTI000540
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the WW-binding motif of Tumor protein p73 (TP73), abrogating binding to Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1). Isoforms lacking WW-binding motifs have decreased transcriptional activity.

Participants:
(1) Tumor protein p73 (TP73)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 TP73 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (409PVLSPM414) in Tumor protein p73 (TP73)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
Alternative splicing Abrogation of the Tumor protein p73 (TP73) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Pin1 links the activities of c-Abl and p300 in regulating p73 function.
Mantovani et al. Mol. Cell (2004)




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