Switch #:
SWTI000536
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the sumoylation motif of Heat shock factor protein 4 (HSF4), abrogating binding to SUMO-conjugating enzyme UBC9 (UBE2I). The phosphorylation-dependent sumoylation of the PDSM (phosphorylation-dependent sumoylation motif) strongly represses Isoform HSF4B of Heat shock factor protein 4 (HSF4) activity.

Participants:
(1) Heat shock factor protein 4 (HSF4)
(2) SUMO-conjugating enzyme UBC9 (UBE2I)

Interactions
Interaction #1 HSF4 - UBE2I

Interfaces
(1) MOD_SUMO motif (292LKEE295) in Heat shock factor protein 4 (HSF4)
(2) Ubiquitin-conjugating enzyme (8-152) in SUMO-conjugating enzyme UBC9 (UBE2I)

Interaction Regulation
Alternative splicing Abrogation of the Heat shock factor protein 4 (HSF4) MOD_SUMO motif - SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme interaction

Context
Switch localisation
ELM curated: nucleus, PML body
References

(1) PDSM, a motif for phosphorylation-dependent SUMO modification.
Hietakangas et al. Proc. Natl. Acad. Sci. U.S.A. (2006)




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